Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pamidronic Acid | HCID 4674 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178511207 | HCID 178511207 | 197.9% |
Reaction Steps
23.5 g of pamidronic acid is added to 400 ml of absolute ethanol. 14.18 g of 96% sodium methoxide is added slowly and the reacture mixture is reacted while refluxing for 16 hours. After the reaction mixture is cooled to 0° C., filtered, and dried in oven at 80° C., 28.0 g of white disodium (3-amino-1-hydroxypropane) bisphosphonate is obtained (yield 99.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06534674B2 |
|---|
| Source dataset | uspto-grants-2003_03 |
|---|
| ORD ID | ord-0ce4f03df0f04f14b10ff8345d37eb54 |
|---|
| Source note | uspto-grants-2003_03 |
|---|
