Pamidronic Acid → HCID 178511207, compound

HRID 1862083Notes

Reaction equation

HRID 1862083 reaction equation
[CH2:1]([C:4](P(O)(O)=O)([P:6]([OH:9])([OH:8])=[O:7])[OH:5])[CH2:2][NH2:3].C[O-].[Na+:16]>C(O)C>[PH:6](=[O:7])([O-:9])[O-:8].[PH:6](=[O:7])([OH:9])[OH:8].[NH2:3][CH2:2][CH2:1][CH2:4][OH:5].[Na+:16].[Na+:16]

Participants

4

Reactant 2

HCID 4674Pamidronic AcidHCID 10942334Sodium Methoxide

Product 1

HCID 178511207HCID 178511207, compoundYield 197.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

23.5 g of pamidronic acid is added to 400 ml of absolute ethanol. 14.18 g of 96% sodium methoxide is added slowly and the reacture mixture is reacted while refluxing for 16 hours. After the reaction mixture is cooled to 0° C., filtered, and dried in oven at 80° C., 28.0 g of white disodium (3-amino-1-hydroxypropane) bisphosphonate is obtained (yield 99.6%).

Workup

  1. customthe reacture mixture is reacted
  2. temperaturewhile refluxing for 16 hours
  3. filtrationfiltered
  4. customdried in oven at 80° C.

Sources & evidence

ORD record
ord-0ce4f03df0f04f14b10ff8345d37eb54
Source dataset
uspto-grants-2003_03
Patent number
US06534674B2

Reaction notes

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