HCID 18619246, compound → HCID 18619143, compound

HRID 1862252Notes

Reaction equation

HRID 1862252 reaction equation
C([O:8][C:9]1[C:10]([O:16][CH2:17][C:18]([O:20][CH3:21])=[O:19])=[N:11][C:12]([CH3:15])=[N:13][CH:14]=1)C1C=CC=CC=1>[Pd].C(OCC)(=O)C>[OH:8][C:9]1[C:10]([O:16][CH2:17][C:18]([O:20][CH3:21])=[O:19])=[N:11][C:12]([CH3:15])=[N:13][CH:14]=1

Participants

4

Reactant 1

HCID 18619246HCID 18619246, compound

Product 1

HCID 18619143HCID 18619143, compoundYield 103.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 0.21 g of 5-benzyloxy-4-(methoxycarbonyl)methoxy-2-methylpyrimidine, 16 mg of 10% palladium/carbon and 1.5 ml of ethyl acetate was stirred for 3 hours at room temperature under hydrogen atmosphere. The reaction system was purged with nitrogen, then, the reaction solution was filtrated through Celite, and the filtrate was concentrated to obtain 0.15 g of 5-hydroxy-4-(methoxycarbonyl)methoxy-2-methylpyrimidine.

Workup

  1. customThe reaction system was purged with nitrogen
  2. filtrationthe reaction solution was filtrated through Celite
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-2ef1b9f95e5f481eb3fb4600e3a7fa68
Source dataset
uspto-grants-2003_03
Patent number
US06537948B1

Reaction notes

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