Ethanol → HCID 18619211, compound

HRID 1862258Notes

Reaction equation

HRID 1862258 reaction equation
[F:1][C:2]1[C:22]([N:23]2[C:28](=[O:29])[CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[N:25]([CH3:34])[C:24]2=[O:35])=[CH:21][C:5]([O:6][C:7]2[C:8]([O:14][CH:15]([C:17]([O:19][CH3:20])=[O:18])[CH3:16])=[N:9][C:10]([CH3:13])=[N:11][CH:12]=2)=[C:4]([N+:36]([O-])=O)[CH:3]=1.C(O)C>[Pt]=O.C(OCC)(=O)C>[NH2:36][C:4]1[CH:3]=[C:2]([F:1])[C:22]([N:23]2[C:28](=[O:29])[CH:27]=[C:26]([C:30]([F:31])([F:33])[F:32])[N:25]([CH3:34])[C:24]2=[O:35])=[CH:21][C:5]=1[O:6][C:7]1[C:8]([O:14][CH:15]([C:17]([O:19][CH3:20])=[O:18])[CH3:16])=[N:9][C:10]([CH3:13])=[N:11][CH:12]=1

Participants

5

Reactant 2

HCID 702EthanolHCID 18619268HCID 18619268, compound

Product 1

HCID 18619211HCID 18619211, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 5-{4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]-2-nitrophenoxy}-4-{1-(methoxycarbonyl)ethoxy}-2-methylpyrimidine, platinum oxide, ethanol and ethyl acetate is stirred for 1.5 hours at room temperature under hydrogen atmosphere. The reaction system is purged with nitrogen, then, the reaction solution is filtrated through Celite, and the filtrate is concentrated to obtain 5-{2-amino-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}-4-{1-(methoxycarbonyl)ethoxy}-2-methylpyrimidine.

Workup

  1. customThe reaction system is purged with nitrogen
  2. filtrationthe reaction solution is filtrated through Celite
  3. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-6ae35cc5ad6a4f95be01ad4c37e30ab4
Source dataset
uspto-grants-2003_03
Patent number
US06537948B1

Reaction notes

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