HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1862274Generated: October 31, 2026
Hydrochloric Acid → 4-(Benzyloxy)pyridin-3-ol
https://huagongshe.com/reaction/1862274
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-Benzyloxy-3-methoxymethoxypyridine | HCID 18619172 | — |
| Product | 4-(Benzyloxy)pyridin-3-ol | HCID 18619206 | 95.3% |
Reaction Steps
A mixture of 0.7 g of 4-benzyloxy-3-methoxymethoxypyridine and 1N hydrochloric acid was stirred for 2 hours at 60° C. The mixture was poured into saturated aqueous sodium bicarbonate solution, extracted with ethyl acetate. The organic layer is washed with saturated saline, dried over anhydrous magnesium sulfate, concentrated to obtain 0.547 g of 4-benzyloxy-3-hydroxypyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06537948B1 |
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| Source dataset | uspto-grants-2003_03 |
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| ORD ID | ord-331f82de50ac43bbaaf12280a2691e1b |
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| Source note | uspto-grants-2003_03 |
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