Water → HCID 178480550, compound

HRID 1862349Notes

Reaction equation

HRID 1862349 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([O:15][C:16]2[CH:21]=[C:20]([N:22]3[C:27](=[O:28])[CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[N:24]([CH3:33])[C:23]3=[O:34])[C:19]([F:35])=[CH:18][C:17]=2[Cl:36])[N:10]=1)C1C=CC=CC=1.O>FC(F)(F)C(O)=O>[Cl:36][C:17]1[CH:18]=[C:19]([F:35])[C:20]([N:22]2[C:27](=[O:28])[CH:26]=[C:25]([C:29]([F:30])([F:31])[F:32])[N:24]([CH3:33])[C:23]2=[O:34])=[CH:21][C:16]=1[O:15][C:11]1[N:10]=[C:9]([OH:8])[CH:14]=[CH:13][N:12]=1

Participants

4

Reactant 2

HCID 962WaterHCID 186191524-Benzyloxy-2-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}pyrimidine

Product 1

HCID 178480550HCID 178480550, compoundYield 36.2%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 1 g of 4-benzyloxy-2-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}pyrimidine in trifluoroacetic acid was stirred for 2 hours at 70° C. This reaction solution was cooled to room temperature, then, poured into water, and filterated to obtain 0.3 g of 2-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}-4-hydroxy-pyrimidine.

Sources & evidence

ORD record
ord-8080833fa025430c9be13a215d3f5b7e
Source dataset
uspto-grants-2003_03
Patent number
US06537948B1

Reaction notes

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