N-bromobutanimide → HCID 135449959, compound

HRID 1862386Notes

Reaction equation

HRID 1862386 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:18]3[C:17](=[O:19])[CH2:16][CH2:15][CH2:14][C:13]=3[NH:12][C:11]3=[CH:20][CH:21]=[N:22][N:10]23)[CH:5]=[CH:6][C:7]=1[Cl:8].[Br:23]N1C(=O)CCC1=O>ClCCl>[Br:23][C:20]1[CH:21]=[N:22][N:10]2[CH:9]([C:4]3[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=3)[C:18]3[C:17](=[O:19])[CH2:16][CH2:15][CH2:14][C:13]=3[NH:12][C:11]=12

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 135494158HCID 135494158, compound

Product 1

HCID 135449959HCID 135449959, compoundYield 83.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Example 6 (0.52 g, 1.56 mmol) in dichloromethane was treated with N-bromosuccinimide (0.28 mg, 1.56 mmol) and allowed to stir at ambient temperature overnight. The mixture was filtered and the filter cake washed with CH2Cl2 to provide the title compound (0.54 g) as a solid.

Workup

  1. filtrationThe mixture was filtered
  2. washthe filter cake washed with CH2Cl2

Sources & evidence

ORD record
ord-6404f7be25d04e4f97fc77cd3c49b62c
Source dataset
uspto-grants-2003_03
Patent number
US06538000B1

Reaction notes

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