HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1862520Generated: November 2, 2026
Methanesulfonic Acid → HCID 23500365, compound
https://huagongshe.com/reaction/1862520
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | 3,5-Dimethoxyaniline | HCID 66301 | — |
| Reactant | Ethyl 3-oxo-2-(2-phenylethyl)butanoate | HCID 219459 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 23500365 | HCID 23500365 | — |
Reaction Steps
Ethyl 2-(2-phenylethyl)acetoacetate (2.70 g) in xylene (5 ml) was treated with 3,5-dimethoxyaniline (1.60 g) at 150° C. as described in example 19a. Methanesulfonic acid (4.0 ml) was added at room temperature and the mixture heated at 80° C. for 1 hour. The product was isolated as described in example 19a. Yield 1.38 g (41%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06538022B1 |
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| Source dataset | uspto-grants-2003_03 |
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| ORD ID | ord-ebd2ed690b634c229a29f94568310a66 |
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| Source note | uspto-grants-2003_03 |
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