Methanesulfonic Acid → HCID 23500365, compound

HRID 1862520Notes

Reaction equation

HRID 1862520 reaction equation
[C:1]1([CH2:7][CH2:8][CH:9]([C:15]([CH3:17])=O)[C:10]([O:12]CC)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:24]=[C:25]([O:27][CH3:28])[CH:26]=1)[NH2:23].CS(O)(=O)=O>C1(C)C(C)=CC=CC=1>[CH3:28][O:27][C:25]1[CH:26]=[C:20]([O:19][CH3:18])[CH:21]=[C:22]2[C:24]=1[C:15]([CH3:17])=[C:9]([CH2:8][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:10](=[O:12])[NH:23]2

Participants

5

Reactant 3

HCID 6395Methanesulfonic AcidHCID 663013,5-DimethoxyanilineHCID 219459Ethyl 3-oxo-2-(2-phenylethyl)butanoate

Product 1

HCID 23500365HCID 23500365, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Conditions

Temperature
80 °C

Procedure

Ethyl 2-(2-phenylethyl)acetoacetate (2.70 g) in xylene (5 ml) was treated with 3,5-dimethoxyaniline (1.60 g) at 150° C. as described in example 19a. Methanesulfonic acid (4.0 ml) was added at room temperature and the mixture heated at 80° C. for 1 hour. The product was isolated as described in example 19a. Yield 1.38 g (41%).

Workup

  1. customThe product was isolated

Sources & evidence

ORD record
ord-ebd2ed690b634c229a29f94568310a66
Source dataset
uspto-grants-2003_03
Patent number
US06538022B1

Reaction notes

Loading…