Hydrochloric Acid → HCID 86588489, compound

Participants

Reaction Steps

To an ice-cooled solution of N-[(R)-1-(t-butoxycarbonyl)-3-piperidylcarbonyl]-2 (S)-acetylamino-β-alanine benzyl ester (2.7 g) was added 4N HCl in ethyl acetate (25.5 ml). The mixture was stirred for 2.5 hours at an ambient temperature, then the solvent was decanted. The residue was washed with diethyl ether several times, and dried in vacuo to give N-[(R)-3-piperidylcarbonyl]-2(S)-acetylamino-β-alanine benzyl ester hydrochloride (2.29 g) as a white powder.

Provenance & Evidence