Hydrochloric Acid → HCID 86588489, compound

HRID 1862529Notes

Reaction equation

HRID 1862529 reaction equation
[CH2:1]([O:8][C:9](=[O:32])[C@@H:10]([NH:28][C:29](=[O:31])[CH3:30])[CH2:11][NH:12][C:13]([C@@H:15]1[CH2:20][CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16]1)=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:33]>C(OCC)(=O)C>[ClH:33].[CH2:1]([O:8][C:9](=[O:32])[C@@H:10]([NH:28][C:29](=[O:31])[CH3:30])[CH2:11][NH:12][C:13]([C@@H:15]1[CH2:20][CH2:19][CH2:18][NH:17][CH2:16]1)=[O:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86588491HCID 86588491, compound

Product 1

HCID 86588489HCID 86588489, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To an ice-cooled solution of N-[(R)-1-(t-butoxycarbonyl)-3-piperidylcarbonyl]-2 (S)-acetylamino-β-alanine benzyl ester (2.7 g) was added 4N HCl in ethyl acetate (25.5 ml). The mixture was stirred for 2.5 hours at an ambient temperature, then the solvent was decanted. The residue was washed with diethyl ether several times, and dried in vacuo to give N-[(R)-3-piperidylcarbonyl]-2(S)-acetylamino-β-alanine benzyl ester hydrochloride (2.29 g) as a white powder.

Workup

  1. customthe solvent was decanted
  2. washThe residue was washed with diethyl ether several times
  3. customdried in vacuo

Sources & evidence

ORD record
ord-fc57c6c3b0b14abb80964ebb8faa9a6d
Source dataset
uspto-grants-2003_03
Patent number
US06538007B1

Reaction notes

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