Ethyl (R)-Nipecotate L-Tartrate → ethyl (3R)-piperidine-3-carboxylate

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Reaction Steps

To a solution of (R)-3-piperidinecarboxylic acid ethyl ester L-tartaric acid salt (30.3 g) in ethyl acetate (300 ml) and water (60 ml), 12% aqueous sodium hydroxide was added to adjust pH to 13. Aqueous layer was extracted with ethyl acetate (60 ml) two times and combined organic layer was dried with sodium sulfate (8 g). Organic layer was concentrated in vacuo to give (R)-3-piperidinecarboxylic acid ethyl ester (15.3 g).

Provenance & Evidence