反应详情

To a solution of (R)-3-piperidinecarboxylic acid ethyl ester L-tartaric acid salt (30.3 g) in ethyl acetate (300 ml) and water (60 ml), 12% aqueous sodium hydroxide was added to adjust pH to 13. Aqueous layer was extracted with ethyl acetate (60 ml) two times and combined organic layer was dried with sodium sulfate (8 g). Organic layer was concentrated in vacuo to give (R)-3-piperidinecarboxylic acid ethyl ester (15.3 g).

1. extractionAqueous layer was extracted with ethyl acetate (60 ml) two times and combined organic layer
2. dry with materialwas dried with sodium sulfate (8 g)
3. concentrationOrganic layer was concentrated in vacuo