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温度

0 °C

To a solution of methyl 2-benzyloxy-5-(2-methoxymethoxyethyl)benzoate (1.34 g) in methanol (15 ml) was added 2N aqueous sodium hydroxide solution (4.0 ml), and the mixture was heated under reflux for 40 minutes with stirring. After the reaction mixture was cooled to 0° C. 2N hydrochloric acid (5.0 ml) was added and the resulting mixture was extracted with dichloromethane. The extract was washed with brine and dried over anhydrous magnesium sulfate. After the solvent was removed under reduced pressure, crystallization of the residue from hexane and diethyl ether (1/1) gave 2-benzyloxy-5-(2methoxymethoxyethyl)benzoic acid (1.23 g).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 40 minutes
3. extractionthe resulting mixture was extracted with dichloromethane
4. washThe extract was washed with brine
5. dry with materialdried over anhydrous magnesium sulfate
6. customAfter the solvent was removed under reduced pressure, crystallization of the residue from hexane and diethyl ether (1/1)