HCID 70007150, compound → HCID 10165003, compound

HRID 1862767Notes

Reaction equation

HRID 1862767 reaction equation
[Si]([O:18][C:19]1[CH:55]=[CH:54][C:22]([O:23][CH2:24][C@@H:25]([OH:53])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:52]=[CH:51][C:33]([NH:34][C:35]3[C:40]([NH:41][C:42]([NH:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH3:50])=[O:43])=[CH:39][CH:38]=[CH:37][N:36]=3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[CH2:45]([NH:44][C:42]([NH:41][C:40]1[C:35]([NH:34][C:33]2[CH:51]=[CH:52][C:30]([CH2:29][CH2:28][NH:27][CH2:26][C@H:25]([OH:53])[CH2:24][O:23][C:22]3[CH:21]=[CH:20][C:19]([OH:18])=[CH:55][CH:54]=3)=[CH:31][CH:32]=2)=[N:36][CH:37]=[CH:38][CH:39]=1)=[O:43])[CH2:46][CH2:47][CH2:48][CH2:49][CH3:50]

Participants

3

Reactant 1

HCID 70007150HCID 70007150, compound

Product 1

HCID 10165003HCID 10165003, compoundYield 87.8%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

N-{2-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-3-pyridinyl}-N′-hexylurea (0.15 g, 0.197 mmol) was reacted according to Procedure H (eluant: 10:1 going to 5:1 chloroform-methanol containing 2% triethylamine) to give the title compound (0.09 g, 0.173 mmol).

Sources & evidence

ORD record
ord-8971a21600b245d0bed16697cd263dbd
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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