Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10163864, compound

HRID 1862768Notes

Reaction equation

HRID 1862768 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:25]=[CH:24][C:7]([NH:8][C:9]2[C:14]([NH:15][C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:6][CH:5]=1.C([Si]([O:43][C:44]1[CH:49]=[CH:48][C:47]([O:50][CH2:51][CH:52]2[CH2:54][O:53]2)=[CH:46][CH:45]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[OH:53][C@H:52]([CH2:51][O:50][C:47]1[CH:48]=[CH:49][C:44]([OH:43])=[CH:45][CH:46]=1)[CH2:54][NH:1][CH2:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([NH:8][C:9]2[C:14]([NH:15][C:16](=[O:23])[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18619670HCID 18619670, compound

Product 1

HCID 10163864HCID 10163864, compoundYield 32.8%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

N-{2-[4-(2-Aminoethyl)anilino]-3-pyridinyl}benzamide (0.1 g, 0.30 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.107 g, 0.265 mmol) according to Procedure G (eluant: 20:1 going to 10:1 chloroform-methanol) to give the title compound (0.064 g, 0.087 mmol).

Sources & evidence

ORD record
ord-f09facf5b8d54ca3b24cd495f3069a85
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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