Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 70008383, compound

HRID 1862770Notes

Reaction equation

HRID 1862770 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[N:15]([C:22]([CH3:24])=[CH2:23])[C:14]2=[O:25])=[CH:9][CH:8]=1.C([Si]([O:43][C:44]1[CH:49]=[CH:48][C:47]([O:50][CH2:51][CH:52]2[CH2:54][O:53]2)=[CH:46][CH:45]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[OH:53][C@H:52]([CH2:51][O:50][C:47]1[CH:48]=[CH:49][C:44]([OH:43])=[CH:45][CH:46]=1)[CH2:54][NH:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[N:15]([C:22]([CH3:24])=[CH2:23])[C:14]2=[O:25])=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18619638HCID 18619638, compound

Product 1

HCID 70008383HCID 70008383, compoundYield 28.3%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

3-[4-(2-Aminoethyl)phenyl]-1-isopropenyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one formate (0.32 g, 0.96 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.433 g, 1.07 mmol) according to Procedure G (eluant: 20:1 going to 10:1 chloroform-methanol) to give the title compound (0.19 g, 0.272 mmol).

Sources & evidence

ORD record
ord-543c79ce5e1c48879b0ff884dfc9aade
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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