HCID 70007043, compound → HCID 70008383, compound

HRID 1862771Notes

Reaction equation

HRID 1862771 reaction equation
[Si]([O:18][C:19]1[CH:51]=[CH:50][C:22]([O:23][CH2:24][C@@H:25]([OH:49])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([N:36]3[C:40]4=[N:41][CH:42]=[CH:43][CH:44]=[C:39]4[N:38]([C:45]([CH3:47])=[CH2:46])[C:37]3=[O:48])=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[OH:49][C@H:25]([CH2:24][O:23][C:22]1[CH:50]=[CH:51][C:19]([OH:18])=[CH:20][CH:21]=1)[CH2:26][NH:27][CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][C:33]([N:36]2[C:40]3=[N:41][CH:42]=[CH:43][CH:44]=[C:39]3[N:38]([C:45]([CH3:47])=[CH2:46])[C:37]2=[O:48])=[CH:32][CH:31]=1

Participants

3

Reactant 1

HCID 70007043HCID 70007043, compound

Product 1

HCID 70008383HCID 70008383, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

3-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)phenyl]-1-isopropenyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (0.19 g, 0.272 mmol) was reacted according to Procedure H (eluant: 10:1 going to 5:1 chloroform-methanol containing 2% triethylamine) to give the title compound (0.108 g, 0.234 mmol).

Sources & evidence

ORD record
ord-2042de9e9d044d70b0ecc1d736a6245b
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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