Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 12045568, compound

HRID 1862774Notes

Reaction equation

HRID 1862774 reaction equation
[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]3[N:21]([C:22]4[CH:30]=[CH:29][C:25]([CH2:26][CH2:27][NH2:28])=[CH:24][CH:23]=4)[C:16]4=[N:17][CH:18]=[CH:19][CH:20]=[C:15]4[N:14]=3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([Si]([O:48][C:49]1[CH:54]=[CH:53][C:52]([O:55][CH2:56][CH:57]2[CH2:59][O:58]2)=[CH:51][CH:50]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[CH:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:13]3[N:21]([C:22]4[CH:30]=[CH:29][C:25]([CH2:26][CH2:27][NH:28][CH2:59][C@H:57]([OH:58])[CH2:56][O:55][C:52]5[CH:53]=[CH:54][C:49]([OH:48])=[CH:50][CH:51]=5)=[CH:24][CH:23]=4)[C:16]4=[N:17][CH:18]=[CH:19][CH:20]=[C:15]4[N:14]=3)=[CH:11][CH:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18619656HCID 18619656, compound

Product 1

HCID 12045568HCID 12045568, compoundYield 42.6%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[2-(4-Cyclohexylphenyl)-3H-imidazo[4,5-b]pyridin-3-yl]phenethylamine (0.37 g, 0.93 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.377 g, 0.93 mmol) according to Procedure G (eluant: 20:1 going to 5:1 chloroform-methanol) to give the title compound (0.317 g, 0.396 mmol).

Sources & evidence

ORD record
ord-60361438c4c3499ebc76fd9266dd1e8f
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

Loading…