Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 18619663, compound

HRID 1862780Notes

Reaction equation

HRID 1862780 reaction equation
C(O)=O.[Cl:4][C:5]1[CH:10]=[C:9]([N:11]2[CH:15]=[CH:14][C:13]([CH3:16])=[N:12]2)[CH:8]=[CH:7][C:6]=1[C:17]1[N:25]([C:26]2[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][NH2:34])=[CH:28][CH:27]=2)[C:20]2=[N:21][CH:22]=[CH:23][CH:24]=[C:19]2[N:18]=1.C([Si]([O:52][C:53]1[CH:58]=[CH:57][C:56]([O:59][CH2:60][CH:61]2[CH2:63][O:62]2)=[CH:55][CH:54]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[Cl:4][C:5]1[CH:10]=[C:9]([N:11]2[CH:15]=[CH:14][C:13]([CH3:16])=[N:12]2)[CH:8]=[CH:7][C:6]=1[C:17]1[N:25]([C:26]2[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][NH:34][CH2:63][CH:61]([OH:62])[CH2:60][O:59][C:56]3[CH:57]=[CH:58][C:53]([OH:52])=[CH:54][CH:55]=3)=[CH:28][CH:27]=2)[C:20]2=[N:21][CH:22]=[CH:23][CH:24]=[C:19]2[N:18]=1

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18619650HCID 18619650, compound

Product 1

HCID 18619663HCID 18619663, compoundYield 49.1%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

2-(4-{2-[2-Chloro-4-(3-methyl-1 H-pyrazol-1-yl)phenyl]-3H-imidazo[4,5-b]pyridin-3-yl}phenyl)-1-ethanamine formate (0.212 g, 0.447 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.18 g, 0.44 mmol) according to Procedure G (eluant: 20:1 going to 5:1 chloroform-methanol) to give the title compound (0.18 g, 0.216 mmol).

Sources & evidence

ORD record
ord-510d7695cb7e4fa488bdf369cc174b30
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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