HCID 70007667, compound → HCID 18619640, compound

HRID 1862783Notes

Reaction equation

HRID 1862783 reaction equation
[Si]([O:18][C:19]1[CH:63]=[CH:62][C:22]([O:23][CH2:24][C@@H:25]([OH:61])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([N:36]3[C:40]4=[N:41][CH:42]=[CH:43][CH:44]=[C:39]4[N:38]=[C:37]3[C:45]3[CH:46]=[C:47]([NH:51][C:52]([NH:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH3:60])=[O:53])[CH:48]=[CH:49][CH:50]=3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[CH2:55]([NH:54][C:52]([NH:51][C:47]1[CH:48]=[CH:49][CH:50]=[C:45]([C:37]2[N:36]([C:33]3[CH:34]=[CH:35][C:30]([CH2:29][CH2:28][NH:27][CH2:26][CH:25]([OH:61])[CH2:24][O:23][C:22]4[CH:21]=[CH:20][C:19]([OH:18])=[CH:63][CH:62]=4)=[CH:31][CH:32]=3)[C:40]3=[N:41][CH:42]=[CH:43][CH:44]=[C:39]3[N:38]=2)[CH:46]=1)=[O:53])[CH2:56][CH2:57][CH2:58][CH2:59][CH3:60]

Participants

3

Reactant 1

HCID 70007667HCID 70007667, compound

Product 1

HCID 18619640HCID 18619640, compoundYield 49.1%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

N-(3-{3-[4-(2-{[(2S)-3-(4-{[tert-butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)phenyl]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N′-hexylurea (0.19 g, 0.22 mmol) was reacted according to Procedure H (eluant: 10:1 going to 5:1 chloroform-methanol containing 1% ammonium hydroxide) to give the title compound (0.067 g, 0.108 mmol).

Sources & evidence

ORD record
ord-e44e1f1503b446eabccd05629654a8e9
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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