HCID 70007497, compound → HCID 70007134, compound

HRID 1862785Notes

Reaction equation

HRID 1862785 reaction equation
[Si]([O:18][C:19]1[CH:65]=[CH:64][C:22]([O:23][CH2:24][C@@H:25]([OH:63])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([N:36]3[C:40]4=[N:41][CH:42]=[CH:43][CH:44]=[C:39]4[N:38]=[C:37]3[CH2:45][CH2:46][C:47]3[CH:52]=[CH:51][C:50]([NH:53][C:54]([NH:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH3:62])=[O:55])=[CH:49][CH:48]=3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[CH2:57]([NH:56][C:54]([NH:53][C:50]1[CH:51]=[CH:52][C:47]([CH2:46][CH2:45][C:37]2[N:36]([C:33]3[CH:34]=[CH:35][C:30]([CH2:29][CH2:28][NH:27][CH2:26][C@H:25]([OH:63])[CH2:24][O:23][C:22]4[CH:21]=[CH:20][C:19]([OH:18])=[CH:65][CH:64]=4)=[CH:31][CH:32]=3)[C:40]3=[N:41][CH:42]=[CH:43][CH:44]=[C:39]3[N:38]=2)=[CH:48][CH:49]=1)=[O:55])[CH2:58][CH2:59][CH2:60][CH2:61][CH3:62]

Participants

3

Reactant 1

HCID 70007497HCID 70007497, compound

Product 1

HCID 70007134HCID 70007134, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

N-[4-(2-{3-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)phenyl]-3H-imidazo[4,5-b]pyridin-2-yl}ethyl)phenyl]-N′-hexylurea (0.195 g, 0.220 mmol) was reacted according to Procedure H (eluant: 10:1 going to 5:1 chloroform-methanol containing 1% ammonium hydroxide) to give the title compound (0.128 g, 0.197 mmol).

Sources & evidence

ORD record
ord-75d7078aab704e5bade68ba6c8a4d63c
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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