HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 20393843, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetamide, N-(4,6-dichloro-5-methyl-2-pyrimidinyl)- | HCID 3043442 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | 1-Methylpiperazine | HCID 53167 | — |
| Product | HCID 20393843 | HCID 20393843 | — |
Reaction Steps
8.8 parts of 2-acetylamino-4,6-dichloro-5-methylpyrimidine are dissolved in 100 parts by volume of tetrahydrofuran in the presence of 4 parts of triethylamine and 4 parts of N-methylpiperazine. The mixture is held for 6 hours at the reflux temperature. The reaction mixture is poured into water and the insoluble material is filtered off which is recrystallised from ethanol. M.p. 202° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04166852 |
| Source dataset | uspto-grants-1979_09 |
| ORD ID | ord-bc63d11841a04678a5e0e1052e1d8732 |
| Source note | uspto-grants-1979_09 |