Water → HCID 20393843, compound

HRID 1862830Notes

Reaction equation

HRID 1862830 reaction equation
[C:1]([NH:4][C:5]1[N:10]=[C:9](Cl)[C:8]([CH3:12])=[C:7]([Cl:13])[N:6]=1)(=O)[CH3:2].[OH2:14]>O1CCCC1.C(N(CC)CC)C.CN1CCNCC1>[C:7]([NH:6][CH:1]1[CH2:2][N:4]([CH3:5])[CH2:1][CH2:2][N:4]1[C:5]1[N:10]=[CH:9][C:8]([CH3:12])=[C:7]([Cl:13])[N:6]=1)(=[O:14])[CH3:8]

Participants

6

Reactant 2

HCID 962WaterHCID 3043442Acetamide, N-(4,6-dichloro-5-methyl-2-pyrimidinyl)-

Product 1

HCID 20393843HCID 20393843, compound

Reagents, catalysts & solvents 3

HCID 8028TetrahydrofuranSolventHCID 8471TriethylamineSolventHCID 531671-MethylpiperazineSolvent

Procedure

8.8 parts of 2-acetylamino-4,6-dichloro-5-methylpyrimidine are dissolved in 100 parts by volume of tetrahydrofuran in the presence of 4 parts of triethylamine and 4 parts of N-methylpiperazine. The mixture is held for 6 hours at the reflux temperature. The reaction mixture is poured into water and the insoluble material is filtered off which is recrystallised from ethanol. M.p. 202° C.

Workup

  1. filtrationthe insoluble material is filtered off which
  2. customis recrystallised from ethanol

Sources & evidence

ORD record
ord-bc63d11841a04678a5e0e1052e1d8732
Source dataset
uspto-grants-1979_09
Patent number
US04166852

Reaction notes

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