Water → HCID 20393835, compound

HRID 1862831Notes

Reaction equation

HRID 1862831 reaction equation
[CH3:1][NH:2][CH:3]1[CH2:8][N:7]([CH3:9])[CH2:6][CH2:5][N:4]1[C:10]1[N:15]=[CH:14][C:13]([S:16][CH3:17])=[C:12]([Cl:18])[N:11]=1.O.[CH2:20]([OH:23])[CH2:21][CH3:22]>[OH-].[K+]>[ClH:18].[CH3:1][NH:2][CH:3]1[CH2:8][N:7]([CH3:9])[CH2:6][CH2:5][N:4]1[C:10]1[N:15]=[CH:14][C:13]([S:16][CH3:17])=[C:12]([O:23][CH2:20][CH2:21][CH3:22])[N:11]=1

Participants

5

Reactant 3

HCID 962WaterHCID 10311-PropanolHCID 20393833HCID 20393833, compound

Product 1

HCID 20393835HCID 20393835, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

20 parts of 2-methylamino-4-N-methylpiperazino-5-methylthio-6-chloro-pyrimidine are dissolved in 130 parts by volume of n-propanol in the presence of 7 parts of caustic potash in pellets. The mixture is held for 2 hours at the reflux temperature, then poured into water. The oil which separates is extracted with ether. The organic phase is washed with water, dried and evaporated. The residue is taken up in petrol ether in which it solidifies. It is recrystallised from the petrol ether. M.p. 90° C.

Workup

  1. extractionThe oil which separates is extracted with ether
  2. washThe organic phase is washed with water
  3. customdried
  4. customevaporated
  5. customIt is recrystallised from the petrol ether

Sources & evidence

ORD record
ord-789c73e871474ed5b834e7e69ed301e1
Source dataset
uspto-grants-1979_09
Patent number
US04166852

Reaction notes

Loading…