Potassium Iodide → HCID 907980, compound

HRID 1862863Notes

Reaction equation

HRID 1862863 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:19])[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[C:8]([CH3:12])[O:9]2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+].[CH2:28](Cl)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>CC(C)=O>[CH2:28]([O:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:19])[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[C:8]([CH3:12])[O:9]2)=[CH:4][CH:3]=1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 53809767-Hydroxy-2-methyl-3-phenyl-4H-chromen-4-one

Product 1

HCID 907980HCID 907980, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

10 g of 7-hydroxy-2-methyl-isoflavone, 10 g of anhydrous potassium carbonate, 1 g of potassium iodide and 12.5 g of benzyl chloride are boiled in 200 ml of anhydrous acetone for 2 hours with stirring, under a reflux condenser. On subjecting the mixture to steam distillation, the crude product precipitating from the water is filtered, dried, and recrystallized from a mixture of 100 ml of methanol and 40 ml of acetone, affording white needle crystals of 7-benzyloxy-2-methyl-isoflavone, m.p. 139°-141° C.

Workup

  1. distillationto steam distillation
  2. customthe crude product precipitating from the water
  3. filtrationis filtered
  4. customdried
  5. customrecrystallized from a mixture of 100 ml of methanol and 40 ml of acetone

Sources & evidence

ORD record
ord-b29f1f2eea0e44a293b3b00796d5ba25
Source dataset
uspto-grants-1979_09
Patent number
US04166862

Reaction notes

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