Methyl Acrylate → HCID 135574094, compound

HRID 1862988Notes

Reaction equation

HRID 1862988 reaction equation
[C:1]([O:5]C)(=O)[CH:2]=[CH2:3].[NH2:7][C:8]1[NH:9][C:10]2[CH:16]=[C:15]([CH3:17])[C:14]([CH3:18])=[CH:13][C:11]=2[N:12]=1>C(O)C>[CH3:17][C:15]1[C:14]([CH3:18])=[CH:13][C:11]2[N:12]=[C:8]3[NH:7][C:1](=[O:5])[CH2:2][CH2:3][N:9]3[C:10]=2[CH:16]=1

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 931255,6-Dimethylbenzimidazol-2-ylamine

Product 1

HCID 135574094HCID 135574094, compoundYield 102.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl acrylate (15 g.) was added to a solution of 2-amino-5,6-dimethylbenzimidazole (27.2 g.) in ethanol (100 ml.). After stirring for 2 days at room temperature, the crystalline precipitate which had formed in the reaction mixture was separated by filtration, washed with ethanol and then with ether, to give 7,8-dimethyl-3,4-dihydropyrimido[1,2-a]-benzimidazol-2(1H)-one (37.2 g.), m.p. 322°-323° C.

Workup

  1. customthe crystalline precipitate which had formed in the reaction mixture
  2. customwas separated by filtration
  3. washwashed with ethanol

Sources & evidence

ORD record
ord-1835a3685b7b41faa1150e9b54d35453
Source dataset
uspto-grants-1979_09
Patent number
US04167569

Reaction notes

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