Ethylenediamine → HCID 12841761, compound

HRID 1863004Notes

Reaction equation

HRID 1863004 reaction equation
[C:1]([C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[O:5][CH2:6][CH:7]1[O:9][CH2:8]1)#[N:2].[CH2:14]([NH2:17])[CH2:15][NH2:16]>O1CCCC1>[C:1]([C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[O:5][CH2:6][CH:7]([OH:9])[CH2:8][NH:16][CH2:15][CH2:14][NH2:17])#[N:2]

Participants

4

Reactant 2

HCID 3301EthylenediamineHCID 126196712-(Oxiran-2-ylmethoxy)benzonitrile

Product 1

HCID 12841761HCID 12841761, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1-(2-cyanophenoxy)-2,3-epoxypropane (93.3 g.) in tetrahydrofuran (700 ml.) is added dropwise during 5 hours to stirred ethylenediamine (600 g.) and the mixture is stirred for a further 16 hours and then evaporated to dryness under reduced pressure. The residue is twice dissolved in water (500 ml.) and then evaporated to dryness, and then twice dissolved in toluene (500 ml.) and then evaporated to dryness. There is thus obtained as residue 1-(2-cyanophenoxy)-3-(β-aminoethylamino)-2-propanol.

Workup

  1. customevaporated to dryness under reduced pressure
  2. dissolutionThe residue is twice dissolved in water (500 ml.)
  3. customevaporated to dryness
  4. dissolutiontwice dissolved in toluene (500 ml.)
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-ecfe34ff66fb400ea43c4309b2da5bf2
Source dataset
uspto-grants-1979_09
Patent number
US04167581

Reaction notes

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