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HRID1863007

反应详情

EQUATION

反应方程式

HRID 1863007 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：Clc1ncccn1
HCID74404

2-Chloropyrimidine

C4H3ClN2

结构：O=C(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCNCC1
HCID3055243

(Piperazin-1-yl)(4-{[7-(trifluoromethyl)quinolin-4-yl]amino}phenyl)methanone

C21H19F3N4O

PRODUCTS

生成物

1
结构：O=C(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCN(c2ncccn2)CC1
HCID20392863

未命名化合物

收率 95.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

CONDITIONS

反应条件

温度
50 °C

PROCEDURE

实验过程

A mixture of 1.30 g (0.0114 mol) of 2-chloropyrimidine, 3.50 g (0.00875 mol) of 1-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperazine, and 1.2 g of triethylamine in 50 ml of ethanol is stirred at 50° C. for 15 hours and at reflux for 8 hours. The mixture is partitioned between methylene chloride and aqueous 1 N sodium hydroxide. The organic phase is dried and concentrated. The residue is re-crystallized from methylene chloride and ethanol to yield 4.00 g of 4-(2-pyrimidinyl)-1-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperazine, of melting point 246°-247.5° C.

WORKUP

后处理

  1. temperatureat reflux for 8 hours
  2. customThe mixture is partitioned between methylene chloride and aqueous 1 N sodium hydroxide
  3. customThe organic phase is dried
  4. concentrationconcentrated
  5. customThe residue is re-crystallized from methylene chloride and ethanol