HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(3-Methylpyrazin-2-yl)-4-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pyrazine, 2-chloro-3-methyl- | HCID 66769 | — |
| Reactant | 1-Piperazinyl(4-((7-(trifluoromethyl)-4-quinolinyl)amino)phenyl)methanone | HCID 3055243 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | 1-(3-Methylpyrazin-2-yl)-4-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperazine | HCID 20392888 | — |
Reaction Steps
In the manner given in Example 6, a mixture of 4-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperazine, 2-chloro-3-methylpyrazine and triethylamine is heated in ethylene glycol at 75° to 95° C. to give 1-(3-methylpyrazin-2-yl)-4-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04167567 |
| Source dataset | uspto-grants-1979_09 |
| ORD ID | ord-0cba007e203c4294a675a627ce89f328 |
| Source note | uspto-grants-1979_09 |