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HRID1863011

反应详情

EQUATION

反应方程式

HRID 1863011 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：Cc1nccnc1Cl
HCID66769

Pyrazine, 2-chloro-3-methyl-

C5H5ClN2

结构：O=C(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCNCC1
HCID3055243

(Piperazin-1-yl)(4-{[7-(trifluoromethyl)quinolin-4-yl]amino}phenyl)methanone

C21H19F3N4O

PRODUCTS

生成物

1
结构：Cc1nccnc1N1CCN(C(=O)c2ccc(Nc3ccnc4cc(C(F)(F)F)ccc34)cc2)CC1
HCID20392888

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：OCCO
溶剂HCID174

Ethylene glycol

C2H6O2

PROCEDURE

实验过程

In the manner given in Example 6, a mixture of 4-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperazine, 2-chloro-3-methylpyrazine and triethylamine is heated in ethylene glycol at 75° to 95° C. to give 1-(3-methylpyrazin-2-yl)-4-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperazine.