Acetic Acid → 5-Nitroso-2,4,6-pyrimidinetriamine

HRID 1863064Notes

Reaction equation

HRID 1863064 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[C:4]([NH2:9])[N:3]=1.C(O)(=O)C.[N:14]([O-])=[O:15].[Na+]>O>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([N:14]=[O:15])=[C:4]([NH2:9])[N:3]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 138632,4,6-TriaminopyrimidineHCID 23668193Sodium Nitrite

Product 1

HCID 705045-Nitroso-2,4,6-pyrimidinetriamine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2,4,6-triamino-5-nitrosopyrimidine was prepared by dissolving 1.0 mole of 2,4,6-triaminopyrimidine in 1040 ml of water and 1.5 moles of acetic acid, maintaining the temperature in the range of about 0°-16° C. Then 1.0 mole of sodium nitrite was added to the reaction mixture while controlling the reaction temperature in the range of 0°-20° C.

Workup

  1. temperaturemaintaining the temperature in the range of about 0°-16° C
  2. customin the range of 0°-20° C.

Sources & evidence

ORD record
ord-bb38db780a59447da987a7f2eca89566
Source dataset
uspto-grants-1979_09
Patent number
US04167633

Reaction notes

Loading…