Triethylamine → 6-Methoxy-8-(1-methyl-4-phthalimidobutylamino)-4-(3-trifluoromethylstyryl)quinoline

Participants

Reaction Steps

A mixture of 8.4 g (0.025 mole) of 8-amino-6-methoxy-4-(3-trifluoromethylstyryl)quinoline, 7.3 g (0.025 mole) of 4-bromo-1-phthalimidopentane and 2.5 g of triethylamine was heated in an oil bath at 130°-135° for 12 hr. The reaction mixture ws dissolved in chloroform and passed through a silica gel column to give 11 g of crude product which was used without further purification. Crystallization from ethanol provided an analytical sample as yellow needles, mp 154°-156°.

Provenance & Evidence