HRID1863102

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID240534

1H-Isoindole-1,3(2H)-dione,2-(4-bromopentyl)-

C13H14BrNO2

结构：COc1cc(N)c2nccc(C=Cc3cccc(C(F)(F)F)c3)c2c1

HCID631320

未命名化合物

PRODUCTS

生成物

结构：COc1cc(NC(C)CCCN2C(=O)c3ccccc3C2=O)c2nccc(C=Cc3cccc(C(F)(F)F)c3)c2c1

HCID632901

未命名化合物

收率 78.6%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

A mixture of 8.4 g (0.025 mole) of 8-amino-6-methoxy-4-(3-trifluoromethylstyryl)quinoline, 7.3 g (0.025 mole) of 4-bromo-1-phthalimidopentane and 2.5 g of triethylamine was heated in an oil bath at 130°-135° for 12 hr. The reaction mixture ws dissolved in chloroform and passed through a silica gel column to give 11 g of crude product which was used without further purification. Crystallization from ethanol provided an analytical sample as yellow needles, mp 154°-156°.

WORKUP

后处理

temperaturewas heated in an oil bath at 130°-135° for 12 hr

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e390b6d44cb54ab3b2826f1612d776c9
来源数据集: uspto-grants-1979_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04167638
来源说明: uspto-grants-1979_09

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]([O:24][CH3:25])[CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[C:7]2[CH:12]=[CH:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=1.Br[CH:27]([CH3:42])[CH2:28][CH2:29][CH2:30][N:31]1[C:35](=[O:36])[C:34]2=[CH:37][CH:38]=[CH:39][CH:40]=[C:33]2[C:32]1=[O:41].C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH3:25][O:24][C:4]1[CH:5]=[C:6]2[C:11](=[C:2]([NH:1][CH:27]([CH3:42])[CH2:28][CH2:29][CH2:30][N:31]3[C:35](=[O:36])[C:34]4=[CH:37][CH:38]=[CH:39][CH:40]=[C:33]4[C:32]3=[O:41])[CH:3]=1)[N:10]=[CH:9][CH:8]=[C:7]2[CH:12]=[CH:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:21])([F:22])[F:23])[CH:15]=1