HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl vinyl ketone → 4-Methyl-5,6-dimethoxy-8-nitroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl vinyl ketone | HCID 6570 | — |
| Reactant | 4,5-Dimethoxy-2-nitroaniline | HCID 4653152 | — |
| Product | 4-Methyl-5,6-dimethoxy-8-nitroquinoline | HCID 619108 | 27% |
Reaction Steps
A Skraup reaction of 4,5 -dimethoxy-2-nitroaniline with methyl vinyl ketone gave a 27% yield of 5,6-dimethoxy-4-methyl-8-nitroquinoline. The yellow compound crystallized well from methanol; mp 126°-127.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04167638 |
| Source dataset | uspto-grants-1979_09 |
| ORD ID | ord-661c5c8caa5b438888ef13e695849321 |
| Source note | uspto-grants-1979_09 |