反应详情

A stirred mixture of 20.9 g (0.111 mole) of 8-amino-6-methoxy-4-methylquinoline and 34.5 g (0.111 mole) of N-(6-bromohexyl)phthalimide was heated in an oil bath (130° ) while 11.2 g (15.4 ml; 0.111 mole) of triethylamine was added dropwise over a period of 45 minutes. The temperature of the bath was kept at 130° for 60 minutes, at 150° for 60 minutes, between 150° and 190° for 30 minutes, and at 190° for 30 minutes. The mixture was cooled then diluted with acetone (100 ml). The precipitate as collected on a filter, washed with acetone (2×50 ml), dried, then discarded. The filtrate was concentrated in vacuo to a dark oil; yield 53 g. The oil was dissolved in 100 ml of dischloromethane, and the solution was chromatographed on a column (40 cm× 8 cm dia) of silica gel (1000 g; activity III) using dichloromethane (1.5 l) as the eluent. Fractions containing the product were combined then concentrated in vacuo; yield 35.5 g (83.7%). That material was satisfactory for conversion to the target compound, however a 93% recovery of analytically pure material (mp 84°-85° ) could be obtained by crystallization from ethanol.

1. additionwas added dropwise over a period of 45 minutes
2. waitat 190° for 30 minutes
3. temperatureThe mixture was cooled
4. customThe precipitate as collected on a filter
5. washwashed with acetone (2×50 ml)
6. customdried
7. concentrationThe filtrate was concentrated in vacuo to a dark oil
8. dissolutionThe oil was dissolved in 100 ml of dischloromethane
9. customthe solution was chromatographed on a column (40 cm× 8 cm dia) of silica gel (1000 g; activity III)
10. additionFractions containing the product
11. concentrationwere combined then concentrated in vacuo