反应详情

A stirred mixture of 2-(5-amino-2-propoxyphenyl)-8-azapurin-6-one (2.02 g), ethyl 2-ethoxy-1-cyclopentenecarboxylate (1.43 g) and dry sulpholane (20 ml) was heated at 125°-130° C. for 2 hours. The solution was then cooled and poured into dilute hydrochloric acid (200 ml; 2 N) and the yellow solid obtained was filtered off and recrystallised from a mixture of petroleum ether (b.p. 60°-80° C.) and ethyl acetate to give 2-[5-(2-ethoxycarbonylcyclopent-1-enylamino)-2-propoxyphenyl]-8-azapurin-6-one (0.85 g), m.p. 164°-165° C.

1. temperaturewas heated at 125°-130° C. for 2 hours
2. temperatureThe solution was then cooled
3. customthe yellow solid obtained
4. filtrationwas filtered off
5. customrecrystallised from a mixture of petroleum ether (b.p. 60°-80° C.) and ethyl acetate