Methylamine → HCID 20392501, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 37.5 g (100 millimoles) of 2-methyl-4,5-di-(chloromethyl)-6-benzyl-pyridin-3-yl acetate hydrochloride (Example 4), 50 ml of dry dimethylsulfoxide and 16 g (500 millimoles) of methylamine is heated for 5 hours at 80° C. in an autoclave. The solvent is stripped off in a high vacuum and the residue is partitioned between methylene chloride and water, taking care that the pH of the aqueous phase is 7.

Provenance & Evidence