Methylamine → HCID 20392501, compound

HRID 1863247Notes

Reaction equation

HRID 1863247 reaction equation
Cl.C([O:5][C:6]1[C:7]([CH3:23])=[N:8][C:9]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:10]([CH2:14]Cl)[C:11]=1[CH2:12]Cl)(=O)C.[CH3:24][NH2:25]>CS(C)=O>[CH3:24][N:25]1[CH2:12][C:11]2[C:6]([OH:5])=[C:7]([CH3:23])[N:8]=[C:9]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:10]=2[CH2:14]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20392509HCID 20392509, compound

Product 1

HCID 20392501HCID 20392501, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 37.5 g (100 millimoles) of 2-methyl-4,5-di-(chloromethyl)-6-benzyl-pyridin-3-yl acetate hydrochloride (Example 4), 50 ml of dry dimethylsulfoxide and 16 g (500 millimoles) of methylamine is heated for 5 hours at 80° C. in an autoclave. The solvent is stripped off in a high vacuum and the residue is partitioned between methylene chloride and water, taking care that the pH of the aqueous phase is 7.

Workup

  1. customthe residue is partitioned between methylene chloride and water

Sources & evidence

ORD record
ord-e6fd9f05dbce4339ad5fb680d9578d06
Source dataset
uspto-grants-1979_09
Patent number
US04168379

Reaction notes

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