Dimethylamine → HCID 20392556, compound

HRID 1863249Notes

Reaction equation

HRID 1863249 reaction equation
[CH3:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N+:3]=1[O-].[CH2:17]=O.[CH3:19][NH:20][CH3:21]>O>[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:19][N:20]([CH3:17])[CH3:21])[CH:5]=[C:4]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:3]=1

Participants

5

Reactant 3

HCID 674DimethylamineHCID 712FormaldehydeHCID 53667259HCID 53667259, compound

Product 1

HCID 20392556HCID 20392556, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 8.6 g (40 millimoles) of 2-methyl-6-benzyl-pyridin-3-ol N-oxide, 5 g of 30% strength aqueous formaldehyde solution, 5.5 g of 40% strength aqueous dimethylamine solution and 9 ml of water is heated for 2 hours at 80° C. It is then evaporated to dryness, the residue is taken up in chloroform, this solution is shaken with active charcoal and filtered, and the solvent is distilled off. 10.2 g of 2-methyl-4-dimethylaminomethyl-6-benzyl-3-pyridin-3-ol N-oxide remain.

Workup

  1. customIt is then evaporated to dryness
  2. filtrationfiltered
  3. distillationthe solvent is distilled off

Sources & evidence

ORD record
ord-df0154df0b15428fa03330a00f55072c
Source dataset
uspto-grants-1979_09
Patent number
US04168379

Reaction notes

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