2,5-Dihydrofuran → HCID 20392514, compound

HRID 1863257Notes

Reaction equation

HRID 1863257 reaction equation
[CH2:1]([C:8]1O[C:10]([O:17]CC)=[C:11]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:20]1[CH2:24][CH:23]=[CH:22][CH2:21]1>>[CH2:1]([C:8]1[C:22]2[CH2:21][O:20][CH2:24][C:23]=2[C:10]([OH:17])=[C:11]([CH2:13][CH:14]([CH3:15])[CH3:16])[N:12]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 155702,5-DihydrofuranHCID 20392482HCID 20392482, compound

Product 1

HCID 20392514HCID 20392514, compound

Procedure

2-Benzyl-4-isobutyl-5-ethoxyoxazole is reacted with 2,5-dihydrofuran, using the method described in Example 22. 38 g of crude 4-benzyl-6-isobutyl-1,3-dihydro-furo[3,4-c]pyridine-7-ol are obtained. Recrystallization from ethyl acetate gives a pure product, melting point 174°-175° C.

Sources & evidence

ORD record
ord-bb6ad29cab854519b3529613fd105eef
Source dataset
uspto-grants-1979_09
Patent number
US04168379

Reaction notes

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