3-Chloro-N,N-dimethyl-1-propanamine → HCID 20336504, compound

Participants

Reaction Steps

12.1 g (50 millimoles) of 4-benzyl-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol are converted to the sodium salt as described in Example I (a) and are reacted with 9.2 g (75 millimoles) of N-(3-chloropropyl)-N,N-dimethylamine. Working up as described in Example I gives 16.0 g of 4-benzyl-6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-yl 3-dimethylaminopropyl ether bishydrochloride, which is recrystallized from isopropanol-ethanol; melting point 202°-204° C. % N: calculated 7.0, found 7.1.

Provenance & Evidence