3-Chloro-N,N-dimethyl-1-propanamine → HCID 20336504, compound
Reaction equation
[CH2:1]([C:8]1[C:13]2[CH2:14][O:15][CH2:16][C:12]=2[C:11]([OH:17])=[C:10]([CH3:18])[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na].[Cl:20][CH2:21][CH2:22][CH2:23][N:24]([CH3:26])[CH3:25]>>[ClH:20].[ClH:20].[CH3:25][N:24]([CH3:26])[CH2:23][CH2:22][CH2:21][O:17][C:11]1[C:12]2[CH2:16][O:15][CH2:14][C:13]=2[C:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[N:9][C:10]=1[CH3:18]Participants
4
Procedure
12.1 g (50 millimoles) of 4-benzyl-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol are converted to the sodium salt as described in Example I (a) and are reacted with 9.2 g (75 millimoles) of N-(3-chloropropyl)-N,N-dimethylamine. Working up as described in Example I gives 16.0 g of 4-benzyl-6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-yl 3-dimethylaminopropyl ether bishydrochloride, which is recrystallized from isopropanol-ethanol; melting point 202°-204° C. % N: calculated 7.0, found 7.1.
Sources & evidence
- ORD record
- ord-7312637248594a6fb61b4796480463d5
- Source dataset
- uspto-grants-1979_09
- Patent number
- US04168379
Reaction notes
Loading…