Phenol → HCID 12531908, compound

HRID 1863281Notes

Reaction equation

HRID 1863281 reaction equation
Br[CH:2]([C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].[C:20]1([OH:26])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>CO>[O:26]([CH:2]([C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 996PhenolHCID 20392609HCID 20392609, compound

Product 1

HCID 12531908HCID 12531908, compoundYield 89.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl α-bromo-α-[p-(phenoxy)phenyl]acetate (6.42 g) is reacted with 2.35 g of phenol in methanol as in Example 16 to afford 6 g of a yellow liquid after distillation (154° C. at 0.15 mm). A 2.2 g portion is purified by chromatography on silica gel (60 g) with benzene eluent to give the product as a white solid, mp 75.5°-77° C. (from pet. ether).

Sources & evidence

ORD record
ord-ca98f12f85a34ad89b499c7d2760e2e4
Source dataset
uspto-grants-1979_09
Patent number
US04168385

Reaction notes

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