反应详情

Aluminum trichloride (11.75 g.; 0.088 mole) was added portionwise to a stirred mixture of the p-chlorophenylacetyl chloride and chlorobenzene (30 ml.). Following addition, the mixture was allowed to stand for 24 hours. The resulting dark brown paste was scooped out and stirred into a slurry of ice and conc. hydrochloric acid which was then extracted with methylene chloride. The organic extracts were washed with 1 N hydrochloric acid, saturated sodium bicarbonate, saturated sodium chloride; dried over sodium sulfate and concentrated in vacuo. Recrystallization from methanol afforded 16.47 g. (71% yield), m.p. 111.5°-114° C.

1. additionaddition
2. extractionwas then extracted with methylene chloride
3. washThe organic extracts were washed with 1 N hydrochloric acid, saturated sodium bicarbonate, saturated sodium chloride
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated in vacuo
6. customRecrystallization from methanol
7. customafforded 16.47 g