Chloroform → HCID 178441764, compound

HRID 1863378Notes

Reaction equation

HRID 1863378 reaction equation
[C:1]([C:5]1[NH:6][CH:7]=[C:8]([CH2:10][OH:11])[N:9]=1)([CH3:4])([CH3:3])[CH3:2].C(Cl)(Cl)Cl>[O-2].[O-2].[Mn+4].O1CCCC1>[C:1]([C:5]1[NH:6][CH:7]=[C:8]([CH:10]=[O:11])[N:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 6212ChloroformHCID 178441765HCID 178441765, compound

Product 1

HCID 178441764HCID 178441764, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A 7.7 gm. portion of 2-tert-butyl-4-imidazolemethanol is added to 100 ml. of chloroform and 100 ml. of tetrahydrofuran and heated gently. A 25 gm. portion of manganese dioxide is added and the mixture is reacted as described in Example 22 giving the desired product as white crystals, m.p. 194°-195° C.

Workup

  1. customthe mixture is reacted

Sources & evidence

ORD record
ord-a0ca52a13ad74b7c872370e2efd87eb4
Source dataset
uspto-grants-1979_09
Patent number
US04168964

Reaction notes

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