Ethyl Acetate → (+/-)-tert-butyl 5-(3-(6-bromo-5-fluoropicolinamido)pyridin-4-yl)-7-methyl-2-oxohexahydrobenzo[d]oxazole-3(2H)-carboxylate

HRID 186342Notes

Reaction equation

HRID 186342 reaction equation
[Br:26][c:27]1[c:28]([F:36])[cH:29][cH:30][c:31]([C:33](=[O:34])[OH:35])[n:32]1.[CH3:37][CH2:38][O:39][C:40]([CH3:41])=[O:42].[NH2:1][c:2]1[cH:3][n:4][cH:5][cH:6][c:7]1[CH:8]1[CH2:9][CH:10]([CH3:25])[CH:11]2[CH:12]([N:13]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[C:14](=[O:16])[O:15]2)[CH2:24]1>>[NH:1]([c:2]1[cH:3][n:4][cH:5][cH:6][c:7]1[CH:8]1[CH2:9][CH:10]([CH3:25])[CH:11]2[CH:12]([N:13]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[C:14](=[O:16])[O:15]2)[CH2:24]1)[C:33]([c:31]1[cH:30][cH:29][c:28]([F:36])[c:27]([Br:26])[n:32]1)=[O:34]

Participants

4

Reactant 3

HCID 8857Ethyl AcetateHCID 534011946-Bromo-5-fluoropicolinic AcidHCID 68409051(+/-)-tert-butyl 5-(3-aminopyridin-4-yl)-7-methyl-2-oxohexahydrobenzo[d]oxazole-3(2H)-carboxylate

Product 1

HCID 72238215(+/-)-tert-butyl 5-(3-(6-bromo-5-fluoropicolinamido)pyridin-4-yl)-7-methyl-2-oxohexahydrobenzo[d]oxazole-3(2H)-carboxylate

Sources & evidence

ORD record
ord-3bd001c3d8a24fa1a3cecd2ce57f1595
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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