Methyl carbazate → HCID 136398811, compound

HRID 1863424Notes

Reaction equation

HRID 1863424 reaction equation
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[C:13]([CH3:15])=O.[C:16]([O:20][CH3:21])(=[O:19])[NH:17][NH2:18]>C1(C)C=CC=CC=1>[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[C:13](=[N:18][NH:17][C:16]([O:20][CH3:21])=[O:19])[CH3:15]

Participants

4

Reactant 2

HCID 80519Methyl carbazateHCID 3288201-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethan-1-one

Product 1

HCID 136398811HCID 136398811, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Methyl 5-methyl-2-phenyl-4-imidazolyl ketone (4.5 gm., 0.023 mole) is refluxed with methyl carbazate (2.4 gm., 0.023 mole) in toluene (112 ml.) for 5 hours. The toluene is removed, and the solid washed with water (3×50 ml.). The solid is recrystallized from methanol to yield the product (1.28 gm., 20.9%), m.p. 201°-201.5° C.

Workup

  1. customThe toluene is removed
  2. washthe solid washed with water (3×50 ml.)
  3. customThe solid is recrystallized from methanol
  4. customto yield the product (1.28 gm., 20.9%), m.p. 201°-201.5° C.

Sources & evidence

ORD record
ord-bcd2f286c8f24d85ade10422601effc7
Source dataset
uspto-grants-1979_09
Patent number
US04168964

Reaction notes

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