Water → HCID 54045193, compound

HRID 1863430Notes

Reaction equation

HRID 1863430 reaction equation
[Br:1]Br.[CH:3]1[C:4]2[N:5]([CH:10]=[N:11][CH:12]=2)[C:6](=[O:9])[NH:7][N:8]=1.O>C(O)(=O)C>[Br:1][C:12]1[N:11]=[CH:10][N:5]2[C:4]=1[CH:3]=[N:8][NH:7][C:6]2=[O:9]

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 12493302HCID 12493302, compound

Product 1

HCID 54045193HCID 54045193, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

A solution of bromine (8.0 gm., 0.05 mole) in acetic acid (10 ml.) is added to a mixture of imidazo[1,5-d]-as-triazin-4(3H)-one (6.8 gm., 0.05 mole) and acetic acid (500 ml.). The reaction mixture is stirred for 1 hour, poured into water and extracted with chloroform. The aqueous layer is separated, made slightly alkaline and extracted with ether. Evaporation of the chloroform and the ether layers yields 5.0 gm. of a solid (46.3%). This solid is recrystallized to afford the title product, a cream colored solid, m.p. 244°-245° C.(d).

Workup

  1. extractionextracted with chloroform
  2. customThe aqueous layer is separated
  3. extractionextracted with ether
  4. customEvaporation of the chloroform
  5. customthe ether layers yields 5.0 gm
  6. customThis solid is recrystallized

Sources & evidence

ORD record
ord-5ba00d7356d64daeb3732d050c27eda5
Source dataset
uspto-grants-1979_09
Patent number
US04168964

Reaction notes

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