Dimethylformamide dimethyl acetal → HCID 20291411, compound

HRID 1863431Notes

Reaction equation

HRID 1863431 reaction equation
[CH3:1]OC(OC)N(C)C.[CH3:9][C:10]1[N:11]=[C:12]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:13]2[C:18]=1[CH:17]=[N:16][NH:15][C:14]2=[O:19]>C1C=CC=CC=1>[CH3:1][N:15]1[C:14](=[O:19])[N:13]2[C:12]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[N:11][C:10]([CH3:9])=[C:18]2[CH:17]=[N:16]1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 13548681HCID 13548681, compound

Product 1

HCID 20291411HCID 20291411, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Dimethylformamide dimethyl acetal (0.73 ml.; d=0.087, 0.005 mole) is added slowly to a slurry of 8-methyl-6-phenylimidazo[1,5-d]-as-triazin-4(3H)-one (1.13 gm., 0.005 mole) in benzene (25 ml.). The reaction mixture is stirred, refluxed for 24 hours, cooled and filtered. The filtrate is evaporated to yield 1.4 gm. (100%) product. Recrystallization from methyl cyclohexane yields yellow crystals, found to be identical (ir; nmr) to the product obtained by Method A.

Workup

  1. temperaturerefluxed for 24 hours
  2. temperaturecooled
  3. filtrationfiltered
  4. customThe filtrate is evaporated
  5. customto yield 1.4 gm
  6. customRecrystallization from methyl cyclohexane
  7. customyields yellow crystals

Sources & evidence

ORD record
ord-4460beb7eb70423a9f622a7acce215fd
Source dataset
uspto-grants-1979_09
Patent number
US04168964

Reaction notes

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